A PSA of 4.2 was discovered on my recent screening blood test for prostate cancer. I am a 45 year old male with no symptoms. Normal PSA ranges are from 0-4.0. However this range includes men of all ages. At 45 years of age, your PSA should be lower than that of older males. A mild elevation often represents prostatitis, which isn’t serious and can be treated with antibiotics. Screening criteria for prostate cancer are very controversial because even though it leads to earlier detection, there is inconclusive evidence that early detection improves health outcomes. The most potential benefit is to those ages 50-70 (starting at 45 in African Americans or those with a close relative with prostate cancer).